Released on: October 9, 2008, 9:04 am

Press Release Author: AnaSpec Inc.

Industry: Biotech

Press Release Summary: The core histones (H2A, H2B, H3 and H4) act as spools around
which DNA winds.

Press Release Body: San Jose, CA - October 8, 2008
The core histones (H2A, H2B, H3 and H4) act as spools around which DNA winds.
Covalent modification on the amino terminal of the core histones through
de/acetylation, de/methylation and de/phosphorylation affect chromatin structure and
exquisitely regulate gene expression.1-3 Histone hyperacetylation is correlated
with increased transcription, whereas hypoacetylation correlates with
transcriptional repression.2
AnaSpec, one of the world's largest provider of on-demand peptides is pleased to
announce the rapid expansion of our histone peptide selection. Histone GO(tm) Peptides
include sequences that are acetylated and di- or tri-methylated.
About AnaSpec

AnaSpec is a leading provider of integrated proteomics solutions to the world's
largest biotech, pharmaceutical, and academic research institutions. With a vision
for innovation through synergy, AnaSpec focuses on three core technologies:
peptides, detection reagents, and combinatorial chemistry.

For more information visit www.anaspec.com
References:
1. Jenuwein, T. and CD. Allis Science 293, 1074 (2001).
2. Sterner, DE. et al. Microbiol. Mol. Biol. Rev. 64, 435 (2000).
3. Lachner, M. et al. J. Cell Sci. 116, 2117 (2003).

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